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Histone H2A (1-129) from Xanopus sp.

品牌
Sigma-Aldrich
货号
SRP6584
规格纯度
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
参考价格
3288.35 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

H2A is a core component of nucleosome. A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around an octamer of histones. The octamer is composed of two of each histone H2A, H2B, H3, and H4. DNA accessibility is regulated via a complex set of post-translational modifications of these histones, also called histone code, and nucleosome remodeling. Histones H2A and H2B form a dimer. Histones H3 and H4 form a tetramer. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core. Histone H3 undergoes many modifications which include acetylation, phosphorylation, ubiquitylation, sumoylation, and biotinylation that are important for regulation of gene transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.

外形

Lyophilized powder. Recommended buffer is 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride, and 20% glycerol.

基本信息

NACRESNA.32

产品性质

生物来源Xenopus laevis
重组expressed in E. coli
测定≥95% (SDS-PAGE)
形式lyophilized powder
分子量 13.9 kDa (1-129 aa)
包装pkg of 100 and 250 μg
UniProt登记号Q16777
运输dry ice
储存温度−70℃
Gene Informationhuman ... HIST2H2AC(8338)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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