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HIF-1 α, C-terminal activation domain (776-826 human

品牌
Sigma-Aldrich
货号
SRP2097
规格纯度
recombinant, expressed in E. coli, ≥85% (SDS-PAGE)
参考价格
5998.7 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The gene encoding it is localized on human chromosome 14q23.2.

生化/生理作用

During hypoxia, the two subunits of this factor undergo post-translational modifications which in turn promote transactivation.
Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. HIF-1α contains two transactivation domains located between amino acids 531 and 826. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified. Specific disruption of the HIF-1 pathway is important for exploring its role in tumor biology and developing more efficient weapons to treat cancer. HIF-1alpha is a master regulator of the hypoxic response, and its proangiogenic activities include, but are not limited to, regulation of vascular endothelial growth factor (VEGF). HIF-1alpha protein expression often seen in invasive breast cancer. Recent data demonstrates that HIF-1alpha knockdown reduces tumorigenicity of MCF-7 cells and suggest a promising combination of both anti-HIF-1 strategy and traditional chemotherapy to improve cancer treatment.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
重组expressed in E. coli
测定≥85% (SDS-PAGE)
形式frozen liquid
分子量 ~6.7 kDa
包装pkg of 10 μg
储存条件avoid repeated freeze/thaw cycles
浓度700 μg/mL
颜色 colorless to clear
NCBI登记号NM_001530
UniProt登记号Q16665
运输dry ice
储存温度−70℃
Gene Informationhuman ... HIF1A(3091)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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