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HDAC6 H611A human

品牌
Sigma-Aldrich
货号
SRP0311
规格纯度
recombinant, expressed in baculovirus infected Sf9 cells, ≥79% (SDS-PAGE)
参考价格
8831.52 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

HDAC6 (histone deacetylase 6) belongs to the HDAC family of proteins. HDACs are responsible for deacetylation of nuclear histone and nonhistone proteins, including transcription factors. The mutation H611A results in catalytically inactive HDAC6.
Human HDAC6 with H611A mutation (GenBank Accession No. NM_006044), full length with N-terminal GST tag, MW= 161kDa, expressed in a Baculovirus expression system.

生化/生理作用

HDAC6 (histone deacetylase 6) is involved in the control of microtubules, growth factor-mediated chemotaxis, stress response in presence of misfolded protein and tumor invasion. It also participates in EGF (epidermal growth factor)-mediated β-catenin nuclear presence and activation of c-myc. In mouse model, HDAC6 is implicated in oncogene-induced tumorigenesis. HDAC6 is the main deacetylase for α-tubulin and thus, is involved in cell motility. It is also involved in the formation of SGs (stress granules) and SG proteins. Mutations in the 3′-UTR of the HDAC6 gene suppresses hsa-miR-433-mediated post-transcriptional regulation. This results in overexpression of HDAC6, thereby causing X-linked chondrodysplasia.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in baculovirus infected Sf9 cells
测定≥79% (SDS-PAGE)
形式aqueous solution
分子量 161 kDa
包装pkg of 50 μg
NCBI登记号NM_006044
UniProt登记号Q9UBN7
运输dry ice
储存温度−70℃
Gene Informationhuman ... HDAC6(10013)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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