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FOLR1 from mouse

品牌
Sigma-Aldrich
货号
SRP6462
规格纯度
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
参考价格
3896.85 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Folate Receptor 1 (FOLR1) also known as Folate receptor α, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.

外形

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

基本信息

NACRESNA.32

产品性质

生物来源mouse
重组expressed in HEK 293 cells
标签6-His tagged (C-terminus)
测定≥95% (SDS-PAGE)
形式lyophilized
分子量calculated mol wt 25.6 kDa
observed mol wt 45-50 kDa by SDS-PAGE (DTT-reduced. Protein migrates due to glycosylation. Thr 25 is the predicted N-terminal.)
包装pkg of 10 and 50 μg
杂质<1 EU/μg endotoxin (LAL test)
UniProt登记号P35846
运输wet ice
储存温度−20℃
Gene Informationmouse ... FOLR1(14275)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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