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Ezetimibe

依泽替米贝

品牌
Sigma-Aldrich
CAS
163222-33-1
货号
SML1629
包装型号
规格纯度
≥98% (HPLC)
参考价格
1698.93 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Ezetimibe is a non statin drug that reduces intestinal cholesterol absorption. In addition, it also has an ability to reduce the risk of cardiovascular events in patients who had had an acute coronary syndrome and whose low-density lipoprotein (LDL) cholesterol values were within guideline recommendations.
Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by Niemann-Pick C1 Like 1 (NPC1L1) protein that was found critical for the intestinal absorption of cholesterol. Ezetimibe selectvely blocks cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen.

重悬

For solubility in aqueous buffer, Ezetimibe should be dissolved in ethanol followed by dilution with the buffer.

基本信息

经验(实验)分子式C24H21F2NO3
分子量409.43
MDL编号MFCD00937872
PubChem化学物质编号329825513
NACRESNA.77

产品性质

质量水平200
测定≥98% (HPLC)
形式powder
溶解性DMF: soluble ≥15 mg/mL
DMSO: soluble ≥15 mg/mL
ethanol: soluble ≥15 mg/mL
methanol: soluble ≥15 mg/mL
储存温度2-8℃
SMILES stringFC(C=C1)=CC=C1N([C@H](C2=CC=C(O)C=C2)[C@H]3CC[C@H](O)C4=CC=C(F)C=C4)C3=O
InChI1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1
InChI keyOLNTVTPDXPETLC-XPWALMASSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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