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Emtricitabine

(-)-2′3′-Dideoxy-5-fluoro-3′-thiacytidine

品牌
Sigma-Aldrich
CAS
143491-57-0
货号
SML3051
规格纯度
≥98% (HPLC)
参考价格
1053.02 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Emtricitabine ((-)-FTC) is an orally active, non-cytotoxic (>100 μM/PBM, CEM, Vero, MT-4), potent nucleoside reverse transcriptase inhibitor (NRTI) against HIV type 1/2 (HIV-1 IC50/culture = 8 nM/PBM (LAV-1), 9 nM/CEM (LAV-1); HIV-2 IC50/culture = 0.7 nM/PBM (ROD2), 100 nM/CEM (Zy)), hepatitis B, as well as simian and feline immunodeficiency viruses. Emtricitabine is activated via 2′-deoxycytidine kinase-mediated phosphorylation to (-)-FTC-5′-triphosphate that inhibits viral reverse transcriptase in a dCTP-competitive manner (HIV-1 Ki = 2.9 μM).

基本信息

经验(实验)分子式C8H10FN3O3S
分子量247.25

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
旋光性[α]/D -150 to -125°, c = 0.25 in methanol
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
InChI1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m0/s1
InChI keyXQSPYNMVSIKCOC-NTSWFWBYSA-N

Sigma-Aldrich

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