位置:首页 > 品牌 > Sigma-Aldrich >

EIF2AK1 (HRI), active, GST tagged human

品牌
Sigma-Aldrich
CAS
1418571-40-0
货号
SRP5321
规格纯度
PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
参考价格
6468.88 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Eukaryotic translation initiation factor 2-α kinase 1 (EIF2AK1) or HRI is a kinase that can be inactivated by hemin. The gene encoding this protein is localized on human chromosome 7p22.1.

生化/生理作用

Eukaryotic translation initiation factor 2-α kinase 1 (EIF2AK1) modulates protein synthesis. It acts at the level of translation initiation to downregulate protein synthesis in response to stress. The protein is activated by heme deficiency and other stimuli and is a major protein kinase that phosphorylates EIF2-α. EIF2AK1 is downregulated in the majority of ovarian cancers compared with normal ovarian tissues. It functions in iron homeostasis and may play a role in hemolytic and inflammatory anemia.

外形

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

制备说明

After opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles.

法律信息

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in baculovirus infected Sf9 cells
产品线PRECISIO®
测定≥70% (SDS-PAGE)
形式buffered aqueous glycerol solution
specific activity9.6-14.4 nmol/min·mg
分子量 ~120 kDa
NCBI登记号NM_014413
application(s)cell analysis
运输dry ice
储存温度−70℃
Gene Informationhuman ... EIF2AK1(27102)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号