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Dr1 (NC2β, 19 kDa), GST tagged human

品牌
Sigma-Aldrich
货号
SRP2124
规格纯度
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
参考价格
5035.36 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Dr1 is a general negative regulator of class II and class III gene expression. It binds to the basic repeat domain of TBP on promoter DNA and can prevent the RNA polymerase II holoenzyme, or its TFIIB and/or TFIIA subunits, from assembling into an initiation complex. Dr1 is phosphorylated in vivo and this modification affects its interaction with TBP. In addition, Dr1 interacts with the hyperphosphorylated form of Pol II and with the repression domain of the AREB6 repressor. Dr1 forms a heterodimer complex with DRAP1 through its histone fold domain. More recently it was discovered that Dr1-DRAP1 is a bi-functional basal transcription factor that differentially regulates gene transcription through DPE (downstream promoter elements) or TATA box motifs. It can stimulate transcription in vitro from Drosophila promoters containing DPEs, whereas it represses transcription from TATA-containing promoters.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

产品性质

生物来源human
重组expressed in E. coli
测定≥80% (SDS-PAGE)
形式frozen liquid
分子量 ~46.2 kDa
包装pkg of 10 μg
浓度500 μg/mL
颜色 colorless to clear
NCBI登记号NM_001938
UniProt登记号Q01658
运输dry ice
储存温度−70℃
Gene Informationhuman ... DR1(1810)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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