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Deltarasin trihydrochloride

品牌
Sigma-Aldrich
CAS
1440898-61-2
货号
SML2154
规格纯度
≥98% (HPLC)
参考价格
2209 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Deltarasin is a membrane-permeable benzimidazole derivative that effectively abolishes cellular KRas plasma membrane localization (5 μM for 1 hr) by blocking KRas-PDEδ interaction via high affinity interaction with PDEδ prenyl-binding pocket (KD = 38 nM). Deltarasin inhibits oncogenic KRas-dependent proliferation (by ~50% of Panc-Tu-I cells; 5μM for 70 hrs) and survival (52% and 46% death induction of Panc-Tu-I and Capan-1 cells, respectively; 5μM for 24 hrs) in human pancreatic ductal adenocarcinoma (PDAC) cultures and is efficacious against Panc-Tu-I xenograft-derived tumor growth in mice in vivo (60% and 80% retardation on day 9, respectively, with 15 mg/kg q.d. or 10 mg/kg b.i.d. via i.p.).

基本信息

经验(实验)分子式C40H37N5O · 3HCl
分子量713.14

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性H2O: 2 mg/mL, clear
储存温度2-8℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3

Sigma-Aldrich

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