产品介绍：
产品说明
生化/生理作用
CHIR-090 is a potent, tight-binding inhibitor against LpxC, the zinc-dependent UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase essential for gram negative bacteria lipid A biosynthesis (98% inhibition of E. coli & A. aeolicus LpxC by 0.5 μg/mL (1.15 μM) CHIR-090 at pH 7.4; A. aeolicus LpxC Ki = 1.0-1.7 nM). CHIR-090 possesses remarkable antibiotic activity comparable to that of ciprofloxacin against P. aeruginosa PAO1 as well as E. coli R477 and R477 [LpxC G17S] strains by antibacterial disk tests (20 μg/2 μL per spot).
基本信息
| 经验(实验)分子式 | C24H27N3O5 |
| 分子量 | 437.49 |
| MDL编号 | MFCD22665727 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 2 mg/mL, clear |
| 储存温度 | −20℃ |
| SMILES string | C[C@H]([C@@H](C(NO)=O)NC(C1=CC=C(C=C1)C#CC2=CC=C(C=C2)CN3CCOCC3)=O)O |
