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CD40L, Soluble mouse

品牌
Sigma-Aldrich
货号
SRP8045
规格纯度
recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)
参考价格
6032.89 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

CD40L (cluster of differentiation 40 ligand), a member of TNF (tumor necrosis factor) superfamily, is a membrane bound protein. This protein is predominantly expressed transiently by activated CD4+ T cells either as a cell-surface molecule or a secreted multimer protein. Activated B cells, certain DC (dendritic cell) subsets, platelets, and smooth muscle cells also express this protein.

生化/生理作用

CD40L (cluster of differentiation 40 ligand) interacts with its receptor CD40 which in turn helps mediate the interaction between APCs (antigen presenting cells) and lymphocytes. Activated platelets produce CD40L which then participates in multiple processes such as endothelial cell reactions, formation of germinal center, T-helper cell priming, and cytotoxic T-cell activation. Platelets are also involved in the pathogenesis of asthma through CD40L where they inhibit the production of regulatory T-cells and promote polarization of T-helper cells. Studies in mice show that this protein confers protection against influenza virus, though in a CD4+ T cell independent manner.

外形

Lyophilized from PBS.

重悬

Reconstitute with 100 μL deionized water.

其他说明

Mouse CD40L (aa 115-260) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag.

法律信息

FLAG is a registered trademark of sigma-aldrich Co. LLC

基本信息

NACRESNA.32

产品性质

生物来源mouse
重组expressed in CHO cells
标签FLAG® tagged
测定>95% (SDS-PAGE)
形式lyophilized
分子量 35-40 kDa
包装pkg of 10 μg
储存条件avoid repeated freeze/thaw cycles
杂质<0.01 EU/μg endotoxin, tested
UniProt登记号P27548
运输wet ice
储存温度−20℃
Gene Informationmouse ... Cd40lg(21947)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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