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C-176

品牌
Sigma-Aldrich
CAS
314054-00-7
货号
SML2559
规格纯度
≥98% (HPLC)
参考价格
1081.94 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

C-176 is a potent and selective inhibitor against murine, but not human, stimulator of interferon genes (STING) via covalent modifiation of mSTING Cys91. C-176 inhibits STING-mediated IFNβ reporter activity (IC50 <50 nM) without affecting RIG-I, and blocks (1 μM) downstream TBK1 phosphorylation induction by STING agonist CMA (1.4 h) in mSTING-expressing HEK293T cells. C-176 markedly reduces CMA-induced serum IL-6 & type I IFNs in mice (by ≥85% 4 h post CMA; 750 nmol C-176/mouse i.p. 1 or 4 h prior to 224 mg/kg CMA) and significantly ameliorates the autoinflammatory severity in Trex1−/− mice.

基本信息

经验(实验)分子式C11H7IN2O4
分子量358.09
MDL编号MFCD00784208

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to very dark gray
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringO=C(NC1=CC=C(I)C=C1)C2=CC=C([N+]([O-])=O)O2

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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