产品说明
一般描述
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. The isolated individual or tandem bromodomains of BRD2 and BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease. This protein can be used for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
外形
50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | human |
| 重组 | expressed in E. coli |
| 测定 | ≥90% (SDS-PAGE) |
| 形式 | liquid |
| 分子量 | 71.2 kDa (65-459 aa + GST Tag) |
| 包装 | pkg of 100 μg pkg of 20 μg |
| NCBI登记号 | NM_005104 |
| UniProt登记号 | P25440 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... BRD2(6046) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H317 - H319 - H412 |
| 预防措施声明 | P273 - P280 - P305 + P351 + P338 - P333 + P313 - P337 + P313 |
| 危险分类 | Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1 |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
