产品介绍：
产品说明
生化/生理作用
BMS-378806 (BMS-806) is a potent and selective HIV-1 attachment inhibitor that blocks HIV glycoprotein 120 (gp120) from interacting with host T-cell surface glycoprotein CD4 (IC50 = 100 nM against CD4 for binding gp120; CYP1A2/2C9/2C19/2D6/3A4 IC50 >23 μM) without affecting HIV integrase, protease, or reverse transcriptase activity. BMS-806 effectively prevents various HIV-1 isolates from replication (EC50 from 0.85 to 26.5 nM in MT-2 and PM1 cultures; host cytotoxicity IC50 >300 μM) without affecting HIV-2, SIV, MuLV, RSV, HCMV, BVDV, VSV, or influenza virus.
基本信息
| 经验(实验)分子式 | C22H22N4O4 |
| 分子量 | 406.43 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to gray |
| 溶解性 | DMSO: 2 mg/mL, clear |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
