产品说明
一般描述
APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. APRIL is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.
外形
Lyophilized from PBS.
重悬
Reconstitute with 100 μL deionized water.
其他说明
The extracellular domain of mouse APRIL (aa 88-232) is fused at the N-terminus to mouse ACRP30headless (aa 18-110) and a FLAG®-tag.
法律信息
FLAG is a registered trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | mouse |
| 重组 | expressed in HEK 293 cells |
| 标签 | FLAG® tagged |
| 测定 | >95% (SDS-PAGE) |
| 形式 | lyophilized |
| 分子量 | ~34 kDa by SDS-PAGE |
| 包装 | pkg of 10 μg |
| 储存条件 | avoid repeated freeze/thaw cycles |
| 杂质 | <0.02 EU/μg endotoxin, tested |
| 颜色 | white |
| UniProt登记号 | Q9D777 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | mouse ... Tnfsf13(69583) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
