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Apoptolidin A Ready Made Solution

品牌
Sigma-Aldrich
CAS
194874-06-1
货号
SML0907
规格纯度
1 mg/mL in DMSO
参考价格
9171.43 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Chemical structure: macrolide

生化/生理作用

Apoptolidin A is a 20-membered macrolide shown to be selectively cytotoxic against several cancer cell lines and noncytotoxic against normal cells. The molecule was originally produced by Nocardiopsis species, and its target site was identified as mitochondrial F0F1-ATPase.
Apoptolidin induces apoptosis selectively in rat glia cells transformed with the adenovirus oncogene E1A. Several minor apoptolidin congeners were isolated, known as Apoptolidins A-D. All apoptolidins were reported to inhibit growth of H292 cancer cells (lung carcinoma) in the submicromolar range. Recently, a stereo-selective synthesis of the Apoptolidin disaccharide was reported.

基本信息

经验(实验)分子式C58H96O21
分子量1129.37
EC 号200-664-3
PubChem化学物质编号329825615

产品性质

质量水平200
生物来源Amycolatopsis sp.
形式DMSO solution
浓度1 mg/mL in DMSO
作用机制enzyme | inhibits
抗生素抗菌谱fungi
运输dry ice
储存温度−20℃
SMILES stringCC(/C=C1\C)=C\C(C)=C\[C@@H](C)[C@H](O[C@H]2[C@@H](O)[C@H](O)[C@@H](OC)[C@H](C)O2)/C=C/C(C)=C/CC[C@H](O)[C@@H](OC)CC([C@H]([C@]3([C@H](C)[C@@H](O)[C@@H](C)C(C[C@H](COC)O[C@H]4C[C@@](O)(C)[C@@H](O[C@H]5C[C@@H](OC)[C@H](O)[C@H](C)O5)[C@H](C)O4)O3)O)O)OC1=O
InChI1S/C58H96O21/c1-29-17-16-18-40(59)43(69-13)25-45(76-55(65)33(5)23-31(3)21-30(2)22-32(4)41(20-19-29)77-56-51(63)50(62)52(71-15)37(9)74-56)53(64)58(67)35(7)48(60)34(6)42(79-58)24-39(28-68-12)75-47-27-57(11,66)54(38(10)73-47)78-46-26-44(70-14)49(61)36(8)72-46/h17,19-23,32,34-54,56,59-64,66-67H,16,18,24-28H2,1-15H3/b20-19+,29-17+,30-22+,31-21+,33-23+/t32-,34+,35-,36+,37+,38+,39-,40+,41-,42?,43+,44-,45?,46+,47+,48+,49-,50+,51+,52+,53-,54+,56+,57+,58-/m1/s1
InChI keyWILMROCKORZEMQ-XIQAQMKHSA-N

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2
闪点(F)188.6 °F
闪点(C)87 ℃

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