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Antithrombin III human

品牌
Sigma-Aldrich
货号
SAE0102
规格纯度
recombinant,carrier-free,expressed in HEK 293 cells
参考价格
3924.49 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Recombinant human antithrombin III (AT-III) is expressed in human HEK 293 cells as a glycoprotein with a calculated molecular mass of 49 kDa (amino acids 33-464). This protein is manufactured in human cells, with no serum. The human cells expression system allows human-like glycosylation and folding, and often supports higher specific activity of the protein. The protein is produced with no artificial tags.

应用

This recombinant human AT-III product can be used to study the mode of action of the enzyme, as well as its potential inhibitors. It may also be used as a standard, e.g. in antithrombin activity assay, and/or in in vivo studies.

生化/生理作用

Antithrombin III (AT-III), or Serpin C1 is a serine protease inhibitor glycoprotein, is a member of the Serpin superfamily. Antithrombin III inactivates several components in the coagulation system, IIa,IXa and mainly thrombin and factor Xa. The inhibitory activity of Antithrombin III is potentiated and increased by the polysaccharide heparin. In addition to its abolishment of coagulation, Antithrombin III was also found to suppress proinflammatory mediators, in part by its anticoagulation action. Congenital antithrombin deficiency results in loss of Antithrombin III activity, and leads to thrombosis. Thus, human Antithrombin III enzyme may be prescribed for the treatment and prevention of thromboembolism, as well as for the prevention of perioperative and peripartum thromboembolism.

产品性质

重组expressed in HEK 293 cells
测定≥95% (SDS-PAGE)
形式lyophilized powder
质量IC50 ≤ 5 nM antithrombin III
specific activity IC50 ≤ 5 nM antithrombin III, (Measured by the ability of antithrombin III to inhibit the activity of thrombin in the presence of heparin. )
杂质≤1.0 EU/μg (LAL test)
UniProt登记号P01008
运输ambient
储存温度−20℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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