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Anti-VAPB antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1411626
规格纯度
purified immunoglobulin, buffered aqueous solution
参考价格
4618.16 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Vesicle-associated membrane protein-associated protein (VAPB) is encoded by the gene mapped to human chromosome 20q13.32. The encoded protein is characterized with a major sperm protein (MSP) domain and amphipathic helical structure, which might form coiled/coil protein-protein interaction motif and a hydrophobic C- terminus. VAPB is ubiquitously expressed and is localized to the intracellular membranes, such as endoplasmic reticulum (ER) and the Golgi apparatus.
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. (provided by RefSeq)

免疫原

VAPB (AAH01712, 1 a.a. ~ 243 a.a) full-length human protein.

Sequence
MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENDKPHDVEINKIISTTASKTETPIVSKSLSSSLDDTEVKKVMEECKRLQGEVQRLREENKQFKEEDGLRMRKTVQSNSPISALAPTGKEEGLSTRLLALVVLFFIVGVIIGKIAL

生化/生理作用

Vesicle-associated membrane protein-associated protein (VAPB) facilitates endoplasmic reticulum (ER)-Golgi transport and secretion. In addition, it is also involved in various processes, such as ER stress and the unfolded protein response (UPR) and bouton formation at the neuromuscular junction. VAPB acts along with protein tyrosine phosphatase-interacting protein 51 (PTPIP51) to regulate calcium homeostasis. Mutation in the gene is associated with development of various disorders, such as amyotrophic lateral sclerosis 8 (ALS8), late-onset spinal muscular atrophy finkel type.

外形

Solution in phosphate buffered saline, pH 7.4

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 26.73 kDa
species reactivityhuman, mouse
technique(s)western blot: 1 μg/mL
NCBI登记号BC001712
UniProt登记号O95292
运输dry ice
储存温度−20℃
Gene Informationhuman ... VAPB(9217)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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