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Anti-UNG1 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB3501269
规格纯度
affinity isolated antibody
参考价格
4802.96 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

UNG1 Antibody: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. While UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from nuclear DNA that arise through either misincorporation during replication or cytosine deamination, inhibition of UNG1 by uracil glycosylase inhibitor did not lead to increased levels of spontaneous or induced mitochondrial DNA mutations. However, decreased levels of UNG activity and increased oxidative damage to mitochondrial DNA were seen in older mice, suggesting that mitochondrial DNA repair mechanisms may be involved in various neurodegenerative disorders in an age-dependent manner. This UNG1 antibody will not cross-react with UNG2.

免疫原

Anti-UNG1 antibody was raised against a peptide corresponding to 14 amino acids near the center of human UNG1. The immunogen is located within amino acids 200-250 of UNG1.

应用

Antibody validated: Western Blot in human and mouse samples; Immunohistochemistry in human samples; Immunofluorescence in human samples. All other applications and species not yet tested.

外形

Supplied in PBS containing 0.02% sodium azide.

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式liquid
species reactivitymouse, human
浓度1 mg/mL
technique(s)immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
同位素/亚型IgG
NCBI登记号NP_003353
UniProt登记号P13051
运输wet ice
储存温度−20℃
Gene Informationhuman ... UNG(7374)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

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