产品说明
一般描述
Uncoordinated 51-like kinase 1 (ULK1) is expressed in skeletal muscle, heart, pancreas, brain, placenta, liver, kidney and lung. This gene is located on human chromosome 2q24.3. ULK1 localizes to cytoplasmic structures. ULK1 and ULK2 is a homolog of autophagy related 1 (Atg1) gene.
特异性
Anti-ULK1 recognizes human ULK1.
应用
Anti-ULK1 has been used in immunoblotting.
生化/生理作用
Uncoordinated 51-like kinase 1 (ULK1) is involved in modulating Atg9 subcellular dynamics. Knockdown of ULK1, but not ULK2, inhibits the autophagic response. Overexpression of ULK1 also inhibits autophagy, suggesting that ULK1 may have multiple mechanisms for regulating autophagy. Knockdown of Ulk1 shRNA can prevent gastric cancer cell survival.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
储存及稳定性
Store at –20 ℃. For continuous use, the product may be stored at 2–8 ℃ for up to one month. For extended storage, freeze in working aliquots at –20 ℃. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~150 kDa |
| species reactivity | human |
| 浓度 | ~1.0 mg/mL |
| technique(s) | western blot: 1-2 μg/mL using whole extracts of HEK-293T cells overexpressing human ULK1. |
| UniProt登记号 | O75385 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... ULK1(8408) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
