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Anti-Tryptophan Hydroxylase antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200723
规格纯度
clone WH-3, purified from hybridoma cell culture
参考价格
6732.28 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Anti-Tryptophan Hydroxylase antibody, Mouse monoclonal (mouse IgG3 isotype) is derived from the WH-3 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with recombinant rabbit Tryptophan Hydroxylase. Tryptophan Hydroxylase (TPH), also known as TpOH, TrpH or L-tryptophan tetrahydropteridine: oxygen oxidoreductase (EC 1.14.16.4) is a member of biopterin-dependent aromatic amino acid hydroxylases family, together with tyrosine hydroxylase and phenylalanine hydroxylase. This gene spanning 29kbp with 11 exons is mapped to human chromosome 11p15.3-p14. This 444 amino acid protein is expressed in the gut, spleen, thymus and also in the pineal gland and the pituitary.

免疫原

recombinant rabbit Tryptophan Hydroxylase.

应用

Anti-Tryptophan Hydroxylase antibody, Mouse monoclonal has been used in:

  • immunoblotting
  • immunohistochemistry
  • immunofluorescence

生化/生理作用

Tryptophan Hydroxylase (TPH) is a rate-limiting tetramer enzyme in the synthetic pathway of neurotransmitter serotonin from L-tryptophan and is considered a key factor for the maintenance of normal serotonin transmission in the central nervous system. The tryptophan hydroxylase 1 gene (TPH1) catalyzes the synthesis of 5-hydroxytryptophan. Mutation in the TPH1 gene leads to schizophrenia, irritable bowel syndrome (IBS) in women, suicidal behavior and depressive disorders.The encoded protein plays a vital role in regulation of cardiovascular function.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

质量水平200
生物来源mouse
抗体形式purified from hybridoma cell culture
antibody product typeprimary antibodies
克隆WH-3, monoclonal
形式buffered aqueous solution
分子量antigen ~55 kDa
species reactivityhuman, rat, mouse, rabbit, sheep
浓度~1.0 mg/mL
technique(s)immunoblotting: 2-4 μg/mL using rabbit pineal gland lysate
immunofluorescence: suitable
immunohistochemistry: suitable
同位素/亚型IgG3
运输dry ice
储存温度−20℃

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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