产品说明
一般描述
Hepatitis A virus cellular receptor 1 (HAVCR1) or T-cell immunoglobulin and mucin protein (TIM-1) is a type 1 transmembrane glycoprotein. The protein is found in the apical membrane of cells. It is expressed in the kidney, testis and activated CD4+ T-cells. It possesses a six-cysteine immunoglobulin-like domain, a T/SP rich domain and two N-glycosylation sites. The TIM-1 gene is localized on human chromosome 5q33.2.
免疫原
TIM-1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human TIM-1.
应用
Anti-TIM-1 antibody produced in rabbit has been used in immunofluorescence.
生化/生理作用
Hepatitis A virus cellular receptor 1 (HAVCR1) regulates susceptibility to human immunodeficiency virus-1 (HIV-1) infection. It is upregulated in injured kidneys. HAVCR1 inhibits the activation of the Ga12 G-protein by blocking its association to GTP. Polymorphisms in the protein have been associated with immune dysfunction.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
联系
The action of this antibody can be blocked using blocking peptide SBP3500252.
外形
Supplied in PBS with 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | predicted mol wt 40 kDa |
| species reactivity | human, mouse |
| technique(s) | immunofluorescence: suitable immunohistochemistry: suitable indirect ELISA: suitable western blot: suitable |
| NCBI登记号 | NP_036338 |
| UniProt登记号 | Q96D42 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... HAVCR1(26762) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
