位置:首页 > 品牌 > Sigma-Aldrich >

Anti-TICAM1 Antibody, clone 3D5.1

品牌
Sigma-Aldrich
货号
MABC663
规格纯度
clone 3D5.1, from mouse
参考价格
5688.25 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

TIR domain-containing adapter molecule 1 (UniProt Q8IUC6), also known as MyD88-3, Proline-rich, vinculin and TIR domain-containing protein B, Putative NF-kB-activating protein 502H, TICAM-1, TIR domain containing adaptor inducing interferon-b, TIR domain-containing adapter protein inducing IFN-b, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon b) is encoded by the TICAM1 gene in human. TCAM-1/TRIF/MyD88-3 is as an adaptor molecule that mediates Toll-like receptor 3 (TLR3)-dependent NF-kB activation and cytokine expression. Upon recognition of double-stranded RNA, TLR3 recruits TRIF, which in turn associates with TNF receptor-associated factor 3 (TRAF3) to activate two Ik-B kinase (IKK)-related kinases, TANK-binding kinase 1 (TBK1) and IKKi. These two kinases phosphorylate interferon regulatory factor 3/7 (IRF3/7), resulting in the induction of type I interferons (IFNs) and expression of IFN-inducible genes. TICAM-1 can also mediate NF-kB activation through receptor-interacting protein 1 (RIP1) and TRAF6. Human enterovirus 68 (EV68) is reported to disable TLR3 pathway signaling by cleaving TRIF in infected cells.

免疫原

GST-tagged recombinant protein corresponding to human TICAM1.

应用

Research Sub Category
Apoptosis - Additional
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected TICAM1 in human liver tissue.
Immunocytochemistry Analysis: 20 µg/mL from a representative lot detected TICAM1 in HeLa and A431 cells.
Anti-TICAM1 Antibody, clone 3D5.1 is an antibody against TICAM1 for use in Western Blotting, Immunohistochemistry, Immunocytochemistry.
Research Category
Apoptosis & Cancer

质量

Evaluated by Western Blotting in Raji cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected TICAM1 in 10 µg of Raji cell lysate.

目标描述

~76 kDa observed

外形

Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆3D5.1, monoclonal
species reactivityhuman
technique(s)immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
同位素/亚型IgG2aκ
NCBI登记号NP_891549
UniProt登记号Q8IUC6
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号