Anti-TH antibody produced in rabbit

产品说明

一般描述

Tyrosine hydroxylase (TH) is a cytoplasmic enzyme. The TH gene codes for a monooxygenase.

免疫原

Recombinant protein fragment contain a sequence corresponding to a region within amino acids 111 and 450 of th according to NP_571224

应用

Anti-th antibody produced in rabbit has been used in:

• western blotting (1:1000)
• whole retinal flat-mount immunolabelling (1:500)
• immunofluorescence (2:1000)
• immunohistochemistry (2:1000)

生化/生理作用

Cell surface-associated protein is implicated in virulence. Promotes bacterial attachment exclusively to the γ-chain of human fibrinogen. Induces formation of bacterial clumps, which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing. Significantly decreases macrophage phagocytosis possibly thanks to the clumps, clumped bacteria being too large to be phagocytosed. Dominant factor responsible for human platelet aggregation, which may be an important mechanism for initiating infective endocarditis. Enhances spleen cell proliferative response in vitro, contributing significantly to the immunostimulatory activity of S.aureus.
Tyrosine hydroxylase (TH), the rate-limiting enzyme of dopamine synthesis, is essential for catecholamine biosynthesis. Its major role is to catalyze the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-DOPA). TH mainly serves as marker furcate cholaminergic neurons. Missense mutations in the TH gene are associated with Segawa′s syndrome, L-DOPA responsive infantile Parkinsonism, or L-DOPA responsive dystonia (DRD).

特点和优势

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外形

1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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