位置:首页 > 品牌 > Sigma-Aldrich >

Anti-TH (C-terminal) antibody produced in goat

抗 TH(C 端) 山羊抗

品牌
Sigma-Aldrich
货号
SAB2501155
规格纯度
affinity isolated antibody, buffered aqueous solution
参考价格
5045.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Tyrosine hydroxylase (TH) is encoded by the gene mapped to human chromosome 11p15.5. The N-terminal end of the protein plays a vital role in maintaining intracellular stability of the enzyme. Tyrosine hydroxylase is expressed in various tissues such as brain, adrenal medulla, and sympathetically innervated tissues. The enzyme is characterized with a regulatory domain (R), a catalytic domain (C) at N-terminal end, and a coiled-coil domain at the C-terminal end.

免疫原

Peptide with sequence CVQDELDTLAHAL, from the C Terminus of the protein sequence according to NP_954986.2; NP_000351.2; NP_954987.2.

生化/生理作用

Tyrosine hydroxylase (TH) specifically catalyzes the hydroxylation of the amino acid L-tyrosine to 3, 4-dihydroxy-L-phenylalanine (L-DOPA). TH is a rate-limiting enzyme involved in the synthesis of catecholamine, which is involved in several brain functions, such as attention, memory, cognition, and emotion. Phosphorylation of the N-terminal portion of tyrosine hydroxylase controls the degradation of this enzyme by the ubiquitin-proteasome pathway. Alteration in the expression of the gene results in the pathogenesis of Parkinson′s disease (PD) and point mutation in the gene coding for TH leads to Segawa′s syndrome.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平100
生物来源goat
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
species reactivityrat, human, canine
technique(s)ELISA: suitable
immunohistochemistry: suitable
western blot: suitable
UniProt登记号P07101
运输dry ice
储存温度−20℃
Gene Informationhuman ... TH(7054)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号