产品说明
一般描述
MAP3K7 (mitogen-activated protein kinase kinase kinase 7) gene encodes a serine/threonine protein kinase that is ubiquitously expressed. It is activated by transforming growth factor-β (TGF-β) and BMP (bone morphogenetic protein) and mediates cellular functions such as transcription regulation and apoptosis. It functions in the p38 and janus kinase (JNK) signaling pathways and also plays an important role in balancing the BMP- and Wnt-signaling pathways. It mediates JNK pathway induced by environmental stresses. It is essential for nuclear factor κB (NF-κB) activation. MAP3K7 gene has been mapped to human chromosome 6q15. Deletions in this region have been observed in cases of prostate cancer indicating its role as a tumor suppressor.
免疫原
Peptide with sequence C-AELDQDEKDQQNT from the internal region of the protein sequence according to NP_003179.1; NP_663304.1.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD02097469 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | goat |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human, rat, mouse |
| technique(s) | indirect ELISA: suitable western blot: suitable |
| UniProt登记号 | O43318 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... MAP3K7(6885) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
