产品说明
一般描述
SMAD7 (mothers against decapentaplegic homolog 7) is a Tbx1 (T-box 1) interacting gene and is encoded by the gene mapped to human chromosome 18q21.1.
免疫原
peptide corresponding to an internal region of human SMAD7, conjugated to KLH. The corresponding sequence is identical in monkey, mouse, rat and bovine
应用
Anti-SMAD7 has been used in western blot analysis and immunofluorescence.
生化/生理作用
SMAD7 (mothers against decapentaplegic homolog 7) is a modulator of TGFβ (transforming growth factorβ) signaling in immune cells which are associated with ulcerative colitis and inflammatory bowel syndrome. It plays a major role in the etiology of CRC (colorectal cancer). In addition, it also acts as a mediator of the negative feedback loop for both the TGFβ and BMP (bone morphogenetic proteins) signaling pathways. It is essential for the remodelling of pharyngeal artery and the enlargement of great vessel. In mouse, homozygous removal of Smad7 causes primarily fourth-related arch artery defects. Silencing of Smad7 in RCD (refractory coeliac disease) biopsy samples can decrease the expression of interleukin-6 and tumour necrosis factor-α. Polymorphism of this gene is associated with colorectal cancer. SMAD7 is an inhibitor of the TGFβ (transforming growth factor beta) /BMP (bone morphogenetic proteins) pathway.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| 人类蛋白质图谱编号 | HPA028897 Human Protein Atlas characterization data |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~46 kDa |
| species reactivity | mouse, monkey, bovine, rat, human |
| 浓度 | ~1.0 mg/mL |
| technique(s) | indirect immunofluorescence: 5-10 μg/mL using human A549 cells. western blot: 2-4 μg/mL using whole extracts of HEK-293 cells over-expressing human SMAD7 |
| UniProt登记号 | O15105 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... SMAD7(4092) mouse ... Smad7(17131) rat ... Smad7(81516) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
