产品说明
一般描述
SMAD3 (SMAD family member 3) is located on chromosome 15q22.
免疫原
Peptide sequence around aa. 206-210 (N-L-S-P-N), according to the protein SMAD3.
生化/生理作用
SMAD3 (SMAD family member 3) plays a major role in the intracellular signaling of transforming growth factorβ(TGFβ). Reducing the phosphorylation level of Smad3 helps autophagy to control endothelial-mesenchymal transition. In arterial smooth muscle cells, suppression of SMAD3 results in elevating cell viability.
特点和优势
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目标描述
Smad3 encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | ~52 kDa |
| species reactivity | human, mouse, rat |
| 浓度 | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 indirect immunofluorescence: 1:100-1:200 |
| 同位素/亚型 | IgG |
| 免疫原序列 | (N-L-S-P-N) |
| NCBI登记号 | NP_001138574.1 |
| UniProt登记号 | P84022 |
| application(s) | research pathology |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... SMAD3(4088) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
