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Anti-SAMD9L antibody produced in rabbit

品牌
Sigma-Aldrich
货号
HPA019488
规格纯度
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab3
参考价格
6389.73 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

SAMD9L (Sterile a motif domain-containing protein 9-like) is an amino-terminal SAM domain containing protein located to human chromosome location 7q21.2. It is ubiquitously expressed in human tissues and is localized in the cytoplasm.

免疫原

Sterile alpha motif domain-containing protein 9-like recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

SAMD9L (Sterile a motif domain-containing protein 9-like) is identified as a tumor suppressor gene. It is involved in cytokine-mediated intracellular signaling. It is down regulated in hepatocellular carcinoma (HCC) patients with hepatitis B virus (HBV) infection. Absence of SAMD9L results in G1-S cell cycle transition and elevated activity of Wnt/β-catenin pathway. It is down regulated in in T and B cells of patients with metastatic melanoma. It has lower expression in breast cancer tissue. In mice, absence of samd9l is associated with myeloid malignancies closely resembling to human diseases with -7/7q-.

特点和优势

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST75081.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

基本信息

人类蛋白质图谱编号HPA019488    Human Protein Atlas characterization data

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
产品线Prestige Antibodies® Powered by Atlas Antibodies
形式buffered aqueous glycerol solution
species reactivityhuman
包装antibody small pack of 25 μL
增强验证independent
Learn more about Antibody Enhanced Validation
technique(s)immunohistochemistry: 1:20- 1:50
免疫原序列EVDTIPKHSICNDKYFYIQMQICKDKIWKQNQNLSLFVREGASSRDILANSKQRDVDFKAFLQNLKSLVASRKEAEEEYGMKAMKKESEGLKLVKLL
UniProt登记号Q8IVG5
运输wet ice
储存温度−20℃
Gene Informationhuman ... SAMD9L(219285)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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