产品说明
免疫原
RWDD3 antibody was raised against a 17 amino acid peptide from near the amino terminus of human RWDD3.
特点和优势
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目标描述
RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune–inflammatory signals. RWDD3 increases Ikbeta sumoylation and stability. In addition, RWDD3 inhibits TNF-alpha-induced kB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikbeta increased stability. RSUME-enhanced sumoylation of Ikbeta leads to the inhibition of NF-kbeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.
联系
The action of this antibody can be blocked using blocking peptide SBP3500105.
外形
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | rat, human, mouse |
| technique(s) | indirect ELISA: suitable western blot: suitable |
| NCBI登记号 | NP_056300 |
| UniProt登记号 | Q9Y3V2 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... RWDD3(25950) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
