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Anti-RING1A antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300706
规格纯度
affinity isolated antibody
参考价格
5045.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The antibody detects endogenous level of total Ring1A protein.

免疫原

Peptide sequence around aa. 35-39 ( I-A-V-S-P), according to the protein NP_002922.2

特点和优势

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目标描述

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of ′Lys-119′ of histone H2A, thereby playing a central role in histone code and gene regulation. H2A ′Lys-119′ ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 ~58 kDa
species reactivityhuman, rat, mouse
浓度1 mg/mL
technique(s)western blot: 1:500-1:1000
同位素/亚型IgG
免疫原序列(I-A-V-S-P)
NCBI登记号NM_002931.3
运输wet ice
储存温度−20℃
Gene Informationhuman ... Ring1A(6015)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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