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Anti-RIG-I (center) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1300231
规格纯度
saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution
参考价格
5045.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. RIG-I contains RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, RIG-I triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). This protein is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV.

免疫原

RIG (NP_055129, 590-624)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human RIG-I.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式saturated ammonium sulfate (SAS) precipitated
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
species reactivityhuman
technique(s)indirect ELISA: 1:1000
NCBI登记号NP_055129
UniProt登记号O95786
运输dry ice
储存温度−20℃
Gene Informationhuman ... RIG(23586)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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