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Anti-PTEN antibody, Rabbit monoclonal

品牌
Sigma-Aldrich
货号
SAB5500169
规格纯度
recombinant, expressed in proprietary host, clone SP218, affinity isolated antibody
参考价格
7114.41 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Phosphatase and tensin homolog deleted on chromosome ten (PTEN), a lipid phosphatase protein, is localized in the cell nucleus. It has a protein tyrosine phosphatase domain. The PTEN gene is located on human chromosome 10q23.

免疫原

Synthetic peptide derived from the C-terminus of human PTEN protein.

生化/生理作用

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a tumor suppressor gene. It negatively regulates the phosphatidylinositol 3-kinase (PI3K) pathway. PTEN protein might control the growth of cells through its lipid phosphatase activity. The protein tyrosine phosphatase domain of PTEN is known to dephosphorylate serine, threonine, and tyrosine residues. It may also participate in immune modulation. Mutation in the PTEN gene is associated with rare bilateral choroidal ganglioneuroma. Germline mutations in the PTEN gene are observed in Cowden′s syndrome (CS), Lhermitte–Duclos disease (LDD), and Bannayan–Zonana syndrome (BZS).

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
重组expressed in proprietary host
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆SP218, monoclonal
species reactivityhuman (tested)
species reactivity (predicted by homology)frog, mouse, dog
technique(s)flow cytometry: 1:200
immunoblotting: 1:400
immunohistochemistry: 1:200
同位素/亚型IgG
UniProt登记号P60484
运输wet ice
储存温度2-8℃
Gene Informationhuman ... PTEN(5728)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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