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Anti-PSEN1 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB2109110
规格纯度
affinity isolated antibody
参考价格
5258.35 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Alzheimer′s disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

免疫原

Synthetic peptide directed towards the middle region of human PSEN1

序列

Synthetic peptide located within the following region: EGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLG

外形

Supplied at 0.5 mg/ml in phosphate-buffered saline, 0.09% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

生物来源rabbit
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 53 kDa
species reactivity (predicted by homology)rat, horse, human, canine, rabbit, guinea pig, mouse, bovine
浓度0.5 mg/mL
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4-8 μg/mL
western blot: 1 μg/mL
NCBI登记号NM_000021
运输wet ice
储存温度−20℃
Gene Informationhuman ... PSEN1(57396)

安全信息

储存分类代码10 - Combustible liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

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