产品说明
一般描述
Monoclonal Anti-Progerin (mouse IgG1 isotype) is derived from the hybridoma 13A4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. A-type lamins, lamin A and lamin C are products of a single gene, LMNA, which are produced by alternative splicing. Prelamin A, the precursor of Lamin A, is farnesylated at its carboxy terminus after synthesis and the last 18 amino acids, which contain the farnesyl group, are removed by the metalloprotease Zmpste24, producing the mature Lamin A. The LMNA gene codes for A-type lamin, lamin A/C.
应用
Monoclonal Anti-Progerin antibody produced in mouse has been used in:
- immunoblotting
- immunoprecipitation
- immunofluorescence
生化/生理作用
Mutations in Lamin A have been linked to a variety of rare human diseases including muscular dystrophy, lipodystrophy, cardiomyopathy, neuropathy and progeroid syndromes (collectively termed laminopathies) and to premature aging (Hutchinson-Gilford progeria syndrome). Lamins A/C participate in maintaining nuclear integrity, modulation of gene expression, cell proliferation and apoptosis.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| 克隆 | 13A4, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~70 kDa |
| species reactivity | human |
| 浓度 | ~1.0 mg/mL |
| technique(s) | immunoprecipitation (IP): suitable indirect immunofluorescence: suitable western blot: 2.5-5.0 μg/mL using whole extracts of HeLa cells overexpressing human progerin. |
| 同位素/亚型 | IgG1 |
| UniProt登记号 | P02545 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... LMNA(4000) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
