产品说明
一般描述
PRKAG2 (protein kinase, AMP-activated, γ2 non-catalytic subunit) is a non-catalytic regulatory subunit of heterotrimeric AMP-activated protein kinase (AMPK), involved in the energy metabolism. It is predominantly present in all subcellular fractions, including the nuclei.
Anti-PRKAG2 Antibody detects endogenous levels of total PRKAG2 protein.
免疫原
The antiserum was produced against synthesized peptide derived from human PRKAG2.
Immunogen Range: 1-50
应用
Anti-PRKAG2, N-Terminal antibody produced in rabbit is suitable for immunohistochemistry and indirect immunofluorescence.
生化/生理作用
PRKAG2 (protein kinase, AMP-activated, γ2 non-catalytic subunit) acts as a sensor of cellular energy status that is controlled by AMP (positively) and ATP (negatively). In normal state CBS domains from AMP-activated protein kinase can bind AMP, ATP, or S-adenosyl methionine. But in mutated condition, it cannot bind. As a result, it leads to hereditary diseases. Its major activity is involved in the regulation of energy homeostasis. It plays an important role in correcting of cell division and chromosome segregation during mitosis. Mutation in PRKAG2 causes Wolff-Parkinson-White (WPW) syndrome, a rare autosomal dominant inheritance disease.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 63 kDa |
| species reactivity | mouse, human |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:20000 immunofluorescence: 1:100-1:500 immunohistochemistry: 1:50-1:100 |
| NCBI登记号 | Q9UGJ0 |
| UniProt登记号 | Q9UGJ0 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PRKAG2(51422) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
