产品说明
一般描述
Polyglutamine-binding protein 1 (PQBP1), also known as PQBP-1, 38 kDa nuclear protein containing a WW domain, Npw38, Polyglutamine tract-binding protein 1, is encoded by the gene name PQBP1/ NPW38/ JM26. Recent studies have implied that PQBP1 may suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. PQBP1 has also been shown to activate transcription directly, or via association with the transcription machinery. PQBP1 might be involved in ATXN1 mutant-induced cell death. PQBP1 has been shown to interact with POU3F2/Brn-2, ATXN1, TXNL4A, HTT and AR. Interaction with ATXN1 correlates positively with the length of the polyglutamine tract. In addition, PQBP1 interacts with RNA polymerase II large subunit in a phosphorylation-dependent manner. PQBP1 forms a ternary complex with ATXN1 mutant and phosphorylated RNA polymerase II. PQBP1 is widely expressed with high levels in heart, skeletal muscle, pancreas, spleen, thymus, prostate, ovary, small intestine and peripheral blood leukocytes. Mutations in PQBP1 have been associated with Renpenning syndrome 1 (RENS1), an X-linked mental retardation syndrome characterized by mental retardation, microcephaly, short stature, and small testes.
免疫原
Epitope: unknown
KLH-conjugated linear peptide corresponding to the unknown of Human PQBP1.
应用
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected PQBP1 in human cardiac myocytes and pancreatic tissue.
Anti-PQBP1 is an antibody against PQBP1 for use in WB, IH.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience
质量
Evaluated by Western Blotting in Human Hippocampus tissue lysate.
Western Blotting Analysis: A 0.5 µg/mL dilution of this antibody detected PQBP1 in 10 µg of Human Hippocampus tissue lysate.
目标描述
~38 kDa observed. Predicted to cross-react to Isoforms 1, 2, 3, and 6. Maybe detected upon longer exposure times.
外形
Purified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Antigen Affinity Purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
其他说明
Concentration: Please refer to lot specific datasheet.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
产品性质
生物来源 | rabbit |
质量水平 | 100 |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
纯化方式 | affinity chromatography |
species reactivity | human |
species reactivity (predicted by homology) | primate (based on 100% sequence homology) |
technique(s) | immunohistochemistry: suitable western blot: suitable |
NCBI登记号 | NP_001027553 |
UniProt登记号 | O60828 |
运输 | wet ice |
Gene Information | human ... PQBP1(10084) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |