产品说明
一般描述
Protein kinase C (PKC) ϲ is an isoenzyme, which belongs to the atypical class of protein kinase C family. PKCϲ is encoded by the gene mapped to human chromosome 1p36.33-p36.2. PKC ϲ is expressed in human eosinophils. This protein is characterized with a PB1 (Phox and Bem1) domain in the N-terminal, a pseudosubstrate (PS) sequence, a C1 domain (or phorbol esters/diacylglycerol binding domain) of a single Cys-rich zinc-finger motif, and a kinase domain in the C-terminal.
免疫原
The antiserum was produced against synthesized peptide derived from human PKC zeta.
Immunogen Range: 526-575
应用
Anti-PKC ϲ, C-Terminal antibody produced in rabbit has been used in immunohistochemistry.
生化/生理作用
Isoenzymes of protein kinase C (PKC) family play a vital role in downstream signaling and cell functions. PKC ϲ regulates adhesion and effector functions of human eosinophils stimulated with platelet-activating factor (PAF) or complement (C) 5a. PKC ϲ and PKC δ might act as a therapeutic target for decreasing eosinophilic inflammation in clinical conditions such as asthma. PKC ϲ is calcium–independent, and is activated by phospholipids including phosphatidic acid (PA), phosphatidylinositol triphosphates and ceramides. Experimental studies state that, PKC ϲ is involved in the mitogen-activated protein kinase (MAPK) cascade, transcriptional factor NF-κB (NF-κB) activation, ribosomal S6-protein kinase signaling, and cell polarity. PKC-ϲ mediates hypoxia-induced Na,K-ATPase endocytosis in the alveolar epithelial cells (AEC).4 PKC-ϲ functions as a potential biomarker for human prostate cancer.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 67 kDa |
| species reactivity | rat, human, mouse |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:1000 immunofluorescence: 1:100-1:500 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI登记号 | Q05513 |
| UniProt登记号 | Q05513 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PRKCZ(5590) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
