产品说明
一般描述
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
免疫原
A synthetic phosphorylated peptide around S89 of human WWTR1.
外形
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | liquid |
| species reactivity | rat, human, mouse |
| 浓度 | 3.06 mg/mL |
| technique(s) | western blot: 1:500-1:2000 |
| UniProt登记号 | Q9GZV5 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... WWTR1(25937) |
安全信息
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
