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Anti-phospho-TDP-43 [pSer409] antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200223
规格纯度
~1.0 mg/mL, affinity isolated antibody
参考价格
5045.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Transactive response DNA-binding protein 43 (TDP-43) belongs to the family of heterogeneous nuclear ribonucleoproteins (hnRNPs). It has two RNA-recognition motifs and a glycine-rich C-terminal sequence. TDP-43 is expressed in heart, lung, liver and brain, which is localized to the nucleus..

免疫原

synthetic peptide containing phosphorylated Ser409 of human TDP-43 conjugated to KLH. The corresponding sequence is identical in mouse TDP-43

应用

Anti-phospho-TDP-43 [pSer409] antibody produced in rabbit has been used in:

  • enzyme linked immuno sorbent assay (ELISA)
  • immunohistochemistry
  • immunoblotting
  • immunofluorescence

生化/生理作用

Transactive response DNA-binding protein 43 (TDP-43) binds to single stranded RNA. It regulates transcription regulation in human immunodeficiency virus (HIV). TDP-43 is the major ubiquinated component of cytoplasmic inclusions in frontotemporal lobe degeneration subtype (FTLD-U) and amyotrophic lateral sclerosis (ALS). Pathological TDP-43 forms abnormal inclusions in neuronal perikarya and neurites. Mutations in TDP-43 is associated with ALS. Abnormal phosphorylation of TDP-43 at Ser409/410 is observed in FTLD-U and ALS, leading to apoptosis.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~43 kDa
species reactivityhuman, mouse
浓度~1.0 mg/mL
technique(s)indirect immunofluorescence: 1-2 μg/mL using HeLa cells
western blot: 1-2 μg/mL using HepG2 and A431 cell lysates
UniProt登记号Q13148
运输dry ice
储存温度−20℃
Gene Informationhuman ... TARDBP(23435)
mouse ... Tardbp(230908)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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