产品说明
一般描述
Transactive response DNA-binding protein 43 (TDP-43) belongs to the family of heterogeneous nuclear ribonucleoproteins (hnRNPs). It has two RNA-recognition motifs and a glycine-rich C-terminal sequence. TDP-43 is expressed in heart, lung, liver and brain, which is localized to the nucleus..
免疫原
synthetic peptide containing phosphorylated Ser409 of human TDP-43 conjugated to KLH. The corresponding sequence is identical in mouse TDP-43
应用
Anti-phospho-TDP-43 [pSer409] antibody produced in rabbit has been used in:
- enzyme linked immuno sorbent assay (ELISA)
- immunohistochemistry
- immunoblotting
- immunofluorescence
生化/生理作用
Transactive response DNA-binding protein 43 (TDP-43) binds to single stranded RNA. It regulates transcription regulation in human immunodeficiency virus (HIV). TDP-43 is the major ubiquinated component of cytoplasmic inclusions in frontotemporal lobe degeneration subtype (FTLD-U) and amyotrophic lateral sclerosis (ALS). Pathological TDP-43 forms abnormal inclusions in neuronal perikarya and neurites. Mutations in TDP-43 is associated with ALS. Abnormal phosphorylation of TDP-43 at Ser409/410 is observed in FTLD-U and ALS, leading to apoptosis.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~43 kDa |
| species reactivity | human, mouse |
| 浓度 | ~1.0 mg/mL |
| technique(s) | indirect immunofluorescence: 1-2 μg/mL using HeLa cells western blot: 1-2 μg/mL using HepG2 and A431 cell lysates |
| UniProt登记号 | Q13148 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... TARDBP(23435) mouse ... Tardbp(230908) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
