产品说明
一般描述
Pseudopodium-enriched atypical kinase 1 (Peak1; KIAA2002, or sgk269) is a ubiquitous non-receptor tyrosine kinase that belongs to the NFK3 family. It interacts with actin filaments via its N-terminal actin-targeting region. It also modulates the activity of multiple cytoskeletal regulatory proteins such as paxillin, p130Cas, Erk, and Crk; and mediates cell proliferation and migration via the Ras/Raf/Erk and Src-p130Cas-Crk-Paxillin pathways. Peak1 may play an important role in the progression of tumors.
特异性
This antibody recognizes Peak phosphorylated at Tyr665.
免疫原
KLH-conjugated linear peptide corresponding to human Peak phosphorylated at Tyr665.
Epitope: Phosphorylated Tyr665
应用
Western Blot Analysis: A representative lot was used by an independent laboratory in 293T cells transfected with wildtype GFP-Peak. (Dr. Richard Klemke, University of California-San Diego.)
This phospho-Peak antibody is validated for use in WB & Dot Blot for the detection of the phospho-Peak protein.
质量
Evaluated by Dot Blot in modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins.
Dot Blot (Specificity) Analysis: A representative lot blocked phospho-Peak (Tyr665) in modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins.
目标描述
220 kDa calculated
外形
Affinity purified
分析说明
Control
Modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
产品性质
生物来源 | rabbit |
质量水平 | 100 |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
纯化方式 | affinity chromatography |
species reactivity | human |
species reactivity (predicted by homology) | mouse (based on 100% sequence homology), orangutan (Sumatran; based on 100% sequence homology), porcine (based on 100% sequence homology), rat (based on 100% sequence homology) |
technique(s) | dot blot: suitable western blot: suitable |
NCBI登记号 | NP_079052 |
UniProt登记号 | Q9H792 |
运输 | wet ice |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |