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Anti-Phospho-NCF4-T154 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5701938
包装型号
规格纯度
参考价格
5406.77 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

免疫原

A synthetic phosphorylated peptide around T154 of human NCF4.

外形

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

产品性质

生物来源rabbit
质量水平100
antibody product typeprimary antibodies
克隆polyclonal
形式liquid
species reactivityrat, mouse, human
浓度0.34 mg/mL
technique(s)western blot: 1:500-1:2000
UniProt登记号Q15080
运输wet ice
储存温度−20℃
Gene Informationhuman ... NCF4(4689)

安全信息

闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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