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Anti-phospho-MAPKAPK5 (pThr182) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4504710
规格纯度
affinity isolated antibody
参考价格
4618.16 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5), also known as MK5 or p38-regulated/activated protein kinase (PRAK), is a novel member of p38 downstream Ser/Thr protein kinase family, with 471 amino acid residues, expressed ubiquitously in human tissues. The protein is characterized with conserved protein kinase domains I–XI.

免疫原

The antiserum was produced against synthesized peptide derived from human MAPKAPK5 around the phosphorylation site of Thr182.

Immunogen Range: 148-197

生化/生理作用

Mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5) plays a vital role in negative regulation of doxorubicin-induced apoptosis in human hepatocellular carcinoma cells (HCC). Reduced expression of MK5 is associated with colon cancerogenesis in humans. PRAK induces phosphorylation of heat shock protein 27 (HSP27) in vivo, in response to cellular stress. PRAK activity is regulated by the p38 pathway. PRAK plays an essential role in tumor suppression and Ras-induced senescence. Decreased expression of PRAK results in increase in mammalian target of rapamycin complex 1 (mTORC1) activity and thus contributes to tumor development. PRAK stimulates various cellular signaling process such as cell cycle, angiogenesis and neuronal plasticity. PRAK might acts as a therapeutic target for Alzheimer′s disease (AD) via interacting with receptor for advanced glycation end products (RAGE)-mediated cell signaling pathway induced by amyloid β (Aβ).

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 54 kDa
species reactivitymouse, human, rat
浓度~1 mg/mL
technique(s)ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号Q8IW41
UniProt登记号Q8IW41
运输wet ice
储存温度−20℃
Gene Informationhuman ... MAPKAPK5(8550)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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