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Anti-phospho-LATS1-T1079/LATS2-T1041 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5701812
包装型号
规格纯度
参考价格
4266.29 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

免疫原

A phospho specific peptide corresponding to residues surrounding T1079 of human LATS1.

外形

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

产品性质

生物来源rabbit
质量水平100
antibody product typeprimary antibodies
克隆polyclonal
形式liquid
species reactivitymouse, human, rat
浓度0.37 mg/mL
technique(s)western blot: 1:500-1:2000
UniProt登记号O95835/Q9NRM7
运输wet ice
储存温度−20℃

安全信息

闪点(F)Not applicable
闪点(C)Not applicable

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