产品说明
一般描述
AKT serine/threonine kinase 1 (AKT1) also called as v-akt murine thymoma viral oncogene homolog 1 or protein kinase B α (PKB α) is encoded by the gene mapped to human chromosome 14q32. It is highly expressed in liver, muscle and adipocytes. The encoded protein is a member of AKT family, which is characterized with an amino-terminal pleckstrin homology (PH) domain, a short α-helical linker and a carboxyl-terminal kinase domain.
特异性
The antibody detects endogenous levels of total pan-AKT protein.
免疫原
Synthetic peptide corresponding to a region derived from internal residues of human RAC-alpha serine/threonine-protein kinase
应用
Anti-pan-AKT antibody produced in rabbit has been used in immunoblotting.
生化/生理作用
AKT serine/threonine kinase 1 (AKT1) acts as a regulator for cell-survival and anti-apoptotic actions which are involved in development of various cancers. This protein has a crucial role in tumorigenesis. In mice, AKT1 is essential for normal development. Mutations in the gene are associated with the pathogenesis of prostate cancer (PC). Elevated expression of the gene has been observed in human gastric cancer. Aberrations in the AKT1 and glycogen synthase kinase 3 (GSK3)-β signaling leads to the development of schizophrenia.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 56 kDa |
| species reactivity | rat, human, mouse |
| 浓度 | 2 mg/mL |
| technique(s) | western blot: 1:500-1:1000 (Cell Lysate) |
| 同位素/亚型 | IgG |
| 登记号 | NP_001014431.1 |
| UniProt登记号 | P31749 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... AKT1(207) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
