产品说明
一般描述
Opioid related nociceptin receptor 1 (OPRL1) is mapped to human chromosome 20q13.33. The gene codes for the nociceptin/orphanin FQ receptor (NOP-R), which is a G protein-coupled receptor expressed at various levels all over the brain and spinal cord. OPRL1 belongs to the opioid receptor family.
The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Two transcript variants encoding the same protein have been found for this gene. (provided by RefSeq)
免疫原
OPRL1 (NP_000904.1, 1 a.a. ~ 370 a.a) full-length human protein.
Sequence
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
生化/生理作用
Opioid related nociceptin receptor 1 (OPRL1) plays a vital role in alcohol and other drug reward pathways. The encoded protein is involved in regulating tolerance and behavioral responses to morphine. Phosphorylation of NOPR at serine 363 by G protein-coupled receptor kinase 3 (GRK3) facilitates arrestin-dependent Jun amino-terminal kinases (JNK) mitogen-activated protein kinase (MAPK) signaling. Mutation in the gene is associated with the risk to develop opiate addiction.
外形
Solution in phosphate buffered saline, pH 7.4
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 40.7 kDa |
| species reactivity | human |
| technique(s) | western blot: 1 μg/mL |
| NCBI登记号 | NM_000913 |
| UniProt登记号 | P41146 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... OPRL1(4987) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
