产品说明
一般描述
NLR family CARD domain containing 3 (NLRC3), also referred to as nucleotide-binding oligomerization domain containing 3 (NOD3), is encoded by the gene mapped to human chromosome 16p13.3. The encoded protein belongs to the NLR protein family and is abundantly expressed in purified T cells, B cells and natural killer (NK) cells, but also in thymus, uterus and kidney.
免疫原
NOD3 antibody was raised against an 18 amino acid peptide near the center of human NOD3.
生化/生理作用
NLR family CARD domain containing 3 (NLRC3) negatively regulates nuclear factor-κB (NF-κB) activity and innate immune signaling induced by the DNA sensor STING (stimulator of interferon gene). NLRC3 inhibits mammalian target of rapamycin (mTOR) pathways involved in providing protection against colorectal cancer. Thus, downregulated expression of the gene has been observed in colorectal cancer and Wegener′s granulomatosis patients.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
联系
The action of this antibody can be blocked using blocking peptide SBP3500544.
外形
Supplied in PBS with 0.02% sodium azide.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human, mouse, rat |
| technique(s) | immunofluorescence: suitable indirect ELISA: suitable western blot: suitable |
| NCBI登记号 | EAW85351 |
| UniProt登记号 | Q7RTR2 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... NLRC3(197358) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
