Anti-NANOS2 Antibody

产品说明

一般描述

Nanos homolog 2 (NANOS2) is a zinc-finger containing, RNA-binding protein belonging to the nanos family. NANOS2 plays an important role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. It has been implicated in germ cell development in both invertebrates and vertebrates. Unlike NANOS1, whose expression in mice is dispensable, the NANOS2 and NANOS3 proteins are required for germ cell development. NANOS2-null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while NANOS3-null PGCs are lost during the migration stage regardless of sex.

特异性

This antibody recognizes the N-terminus of NANOS2.

免疫原

KLH-conjugated linear peptide corresponding to the N-terminus of human NANOS2.

应用

Detect Nanos homolog 2 using this rabbit polyclonal antibody, Anti-NANOS2 Antibody validated for use in western blotting, IHC & Immunofluorescence.
Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected NANOS2 in human brain tissue.

Immunofluorescence Analysis: 20 µg/mL from a representative lot detected NANOS2 in human testis cells.

质量

Evaluated by Western Blotting in rat brain tissue.

Western Blotting Analysis: 2 µg/mL of this antibody detected NANOS2 in 15 µg of rat brain tissue.

目标描述

~15 kDa observed

外形

Antigen Affinity Purified

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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