Anti-MSR1/CD204 Antibody

产品说明

一般描述

Macrophage scavenger receptors (MSR) are membrane glycoproteins that mediate the recognition and uptake of a wide variety of negatively charged macromolecules. There are two types of these receptors that differ in the C-terminal region. MSR has a key role in scavenging a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of MSR is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Ab deposition in Alzheimer′s disease (AD).The observation that the 4 allele of the apolipoprotein E gene is associated with an increased risk for AD has lead to the investigation of lipoprotein metabolism in the brain of AD patients. The type I MSR has been found to be expressed on microglia and Mato cells, but not astrocytes or neurons. In AD brain, MSR type I is strongly expressed by microglia cells that are associated with senile plaques. Because the senile plaques contain AGEs, which are a source of free radicals that could result in oxidative damage to the brain, MSR may have a role in mediating the endocytosis of AGEs.

免疫原

KLH-conjugated linear peptide corresponding to the extracellular domain of human MSR1/CD204.
Epitope: Extracellular domain

应用

Anti-MSR1/CD204 is an antibody against MSR1/CD204 for use in WB, FC.
Flow Cytometry Analysis: 1.0 µg of this antibody from a representative lot detected MSR1/CD204 in 1X10E6 K562 myelogenous leukemia cells.
Research Sub Category
Immunoglobulins & Immunology
Research Category
Inflammation & Immunology

质量

Evaluated by Western Blotting in THP-1 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected MSR1/CD204 in 10 µg of THP-1 cell lysate.

目标描述

~42 & ~49 kDa observed. This antibody is predicted to cross-react with all isoforms of MSR1/CD204 (Isoform 1 - ~49 kDa, Isoform 2 - ~40 kDa, and Isoform 3 - ~42 kDa).

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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