Anti-MLK1 Antibody

产品说明

一般描述

MLK1 (MAP3K9) is a serine–threonine kinase of the Mixed-Lineage Kinase (MLK) family capable of activating the c-Jun N-terminal Kinase (JNK)/Mitogen-Activated Protein Kinase (MAPK) pathway and regulating the other two prinicpal MAPK cascades, p38 and extracellular signal regulated kinase (ERK). Immunoblots and mass spectrometry show MLK is threonine phosphorylated in or near the activation loop. Studies show that MLKs play a role in the TGF-beta1-induced cell death mechanism.

免疫原

KLH-conjugated linear peptide corresponding to human MLK1.

应用

Anti-MLK1 Antibody detects level of MLK1 & has been published & validated for use in IH(P).
Research Category
Signaling
Research Sub Category
Kinases & Phosphatases

质量

Evaluated by Immunohistochemistry in colorectal adenocarcinoma tissue.

Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected MLK1 in colorectal adenocarcinoma tissue.

目标描述

121 kDa (isoform 1), 123 kDa (isoform 2) calculated

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Colorectal adenocarcinoma tissue

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质

安全信息